Ryan received his Ph.D. in Biomedical Sciences from the University of California, Irvine School of Medicine. His thesis work used electrophysiology to define the effects of sodium channel mutations linked to genetic epilepsy syndromes on channel function and neuronal excitability using transgenic Drosophila. These transgenic fly lines carrying human sodium channel mutations were developed into a high throughput screening platform for drug target discovery and anti-seizure drug screening. Following graduation, Ryan received a two year postdoctoral fellowship funded by the California Institute for Regenerative Medicine to develop a platform to examine epilepsy-linked sodium channel mutations using neurons derived from induced pluripotent stem cells. Since joining the Ostrov lab, Ryan’s work focuses on structure-based drug design, lead compound identification, and crystallography to understand protein-protein and ligand-protein interactions.
1. Defining the structural basis for hypersensitivity reactions to small molecule drugs
2. Identification of novel therapeutics for alpha-1 antitrypsin deficiency
3. Molecular modelling/docking and drug development collaborations