Select Publications

Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov DA. The structural basis of HLA-associated drug hypersensitivity syndromes. Immunol Rev. 2012 Nov;250(1):158-66. doi: 10.1111/j.1600-065X.2012.01163.x. PubMed PMID: 23046128.
Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64.
Epub 2012 May 29. PubMed PMID: 22645359; PubMed Central PMCID: PMC3382472. Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. PubMed PMID: 22043012; PubMed Central PMCID: PMC3221928.
Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity. 2008 Aug 15;29(2):228-37. Epub 2008 Jul 31. PubMed PMID: 18674935; PubMed Central PMCID: PMC2603606.
Ostrov DA, Hernández Prada JA, Corsino PE, Finton KA, Le N, Rowe TC. Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening. Antimicrob Agents Chemother. 2007 Oct;51(10):3688-98. Epub 2007 Aug 6. PubMed PMID: 17682095; PubMed Central PMCID: PMC2043263.
Yoder JA, Litman RT, Mueller MG, Desai S, Dobrinski KP, Montgomery JS, Buzzeo MP, Ota T, Amemiya CT, Trede NS, Wei S, Djeu JY, Humphray S, Jekosch K, Hernandez Prada JA, Ostrov DA, Litman GW. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15706-11. Epub 2004 Oct 20. PubMed PMID: 15496470; PubMed Central PMCID: PMC524843.
Ostrov DA, Roden MM, Shi W, Palmieri E, Christianson GJ, Mendoza L, Villaflor G, Tilley D, Shastri N, Grey H, Almo SC, Roopenian D, Nathenson SG. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol. 2002 Jan 1;168(1):283-9. PubMed PMID: 11751972.
Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science. 2000 Oct 27;290(5492):816-9. PubMed PMID: 11052947.
Hernández Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA. Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PubMed PMID: 16799561.
Eason DD, Cannon JP, Haire RN, Rast JP, Ostrov DA, Litman GW. Mechanisms of antigen receptor evolution. Semin Immunol. 2004 Aug;16(4):215-26. Review. PubMed PMID: 15522620.