Full List of Publications

1. Ostrov, D. A., J. Krieger, J. Sidney, A. Sette, and P. Concannon. 1993. T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues. J Immunol 150:4277.PMID: 8482836

2. Hansen, T., G. Balendiran, J. Solheim, D. A. Ostrov, and S. Nathenson. 2000. Structural features of MHC class I molecules that might facilitate alternative pathways of presentation. Immunol Today 21:83. PMID: 10652466

3. Melian, A., G. F. Watts, A. Shamshiev, G. De Libero, A. Clatworthy, M. Vincent, M. B. Brenner, S. Behar, K. Niazi, R. L. Modlin, S. Almo, D. Ostrov, S. G. Nathenson, and S. A. Porcelli. 2000. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with αβ TCRs. J Immunol 165:4494. PMID: 11035089

4. Ostrov, D. A., W. Shi, J. C. Schwartz, S. C. Almo, and S. G. Nathenson. 2000. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816. PMID: 11052947

5. Zhang, W., S. Honda, F. Wang, T. P. DiLorenzo, A. M. Kalergis, D. A. Ostrov, and S. G. Nathenson. 2001. Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3 α and an antigenic peptide bound to MHC class I. J Immunol 167:4396. PMID: 11591764

6. Ostrov, D. A., M. M. Roden, W. Shi, E. Palmieri, G. J. Christianson, L. Mendoza, G. Villaflor, D. Tilley, N. Shastri, H. Grey, S. C. Almo, D. Roopenian, and S. G. Nathenson. 2002. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol 168:283. PMID: 11751972

7. Becker, M. N., W. B. Greenleaf, D. A. Ostrov, and R. W. Moyer. 2004. Amsacta moorei entomopoxvirus expresses an active superoxide dismutase. J Virol 78:10265. PMCID: PM516379

8. Eason, D. D., J. P. Cannon, R. N. Haire, J. P. Rast, D. A. Ostrov, and G. W. Litman. 2004. Mechanisms of antigen receptor evolution. Semin Immunol 16:215. PMID: 15522620

9. Hernandez Prada, J. A., R. N. Haire, J. P. Cannon, G. W. Litman, and D. A. Ostrov. 2004. Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae. Acta Crystallogr D Biol Crystallogr 60:2022. PMID: 15502315

10. Huentelman, M. J., J. Zubcevic, J. A. Hernandez Prada, X. Xiao, D. S. Dimitrov, M. K. Raizada, and D. A. Ostrov. 2004. Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. Hypertension 44:903. PMID: 15492138

11. Sandberg, E. M., D. VonDerLinden, D. A. Ostrov, P. P. Sayeski. 2004. Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction. Mol. Cell. Biochem. 265:161-169. PMID: 15543946

12. Santori, F. R., K. Holmberg, D. Ostrov, N. R. Gascoigne, and S. Vukmanovic. 2004. Distinct footprints of TCR engagement with highly homologous ligands. J Immunol 172:7466. PMID: 15187125

13. Yoder, J. A., R. T. Litman, M. G. Mueller, S. Desai, K. P. Dobrinski, J. S. Montgomery, M. P. Buzzeo, T. Ota, C. T. Amemiya, N. S. Trede, S. Wei, J. Y. Djeu, S. Humphray, K. Jekosch, J. A. Hernandez Prada, D. A. Ostrov, and G. W. Litman. 2004. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A 101:15706. PMCID: PMC524843

14. Sandberg, E. M., D. VonDerLinden, D. A. Ostrov, P. P. Sayeski. 2005. Identification of cyclohexane-1,2,3,4,5,6-hexabromo- as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation. J. Med. Chem., 265:161-9.

15. Hernández Prada, J. A., R. N. Haire, M. Allaire, J. Jakoncic, V. Stojanoff, J. P. Cannon, G. W. Litman, D. A. Ostrov. 2006. Ancient Evolutionary Origin of Diversified Variable Regions Revealed by Crystal Structures of an Amphioxus VCBP. Nature Immunol., 7(8) 875-882. PMID: 16799561

16. Litman, G. W., J. P. Cannon, , L. J. Dishaw, R. N. Haire, D. D. Eason, J. A Yoder, J. A. Hernandez Prada, D. A. Ostrov. 2006. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic Research: Perspectives in Immunology. PMID: 17917037

17. Godeny, M. D., J. Sayyah, D. Vonderflinded, M. Johns, D. A. Ostrov, J. Caldwell-Busby, Sayeski, P. P. 2007. The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT(1) receptor. Cell Signal. 19:600-9. PMID: 17027227

18. Ostrov, D. A., C. L. Barnes, L. E. Smith, S. Binns, T. M. Brusko, A. C. Brown, P. S. Quint, S. A. Litherland, D. C. Roopenian, K. A. Iczkowski. 2007. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue Antigens, 69:181-8. PMID: 17257322

19. Ferreira A.J., J.A. Hernández Prada, D.A. Ostrov, M.K. Raizada. 2008. Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm. Future Cardiol. 4(2):175-182. PMID: 19804294

20. McDoom, I., X. Ma, D. A. Ostrov, and Sayeski, P.P. 2008. Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Autophosphorylation and its Role in Jak2 Activation. Biochemistry. 12;47(32):8326-34. PMID: 18636744

21. Ostrov, D. A., J. A. Hernández Prada, P. E. Corsino, K. A. Finton, N. Le, and T. C. Rowe. 2007. Discovery of Novel DNA Gyrase Inhibitors by High Throughput Virtual Screening. Antimicrob. Agents Chemother. 51(10):3688-98. PMCID: PMC2043263

22. Ostrov, D. A., J. A. Hernández Prada, R. N. Haire, J. P. Cannon, A. T. Magis, K. Bailey, and G. W. Litman. 2007. Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods. Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun. Dec 1;63(Pt 12):1035-7. PMCID: PMC2043263

23. Hernandez Prada, J. A., S. L. Madden, D. A. Ostrov, and M. A. Hernandez. 2008. Molecular modeling optimization of anticoagulant pyridine derivatives. J. Mol. Graph Model. Jun;26(8):1365-9. PMID: 18372200

24. Noorwez, S. M., D. A. Ostrov, J. H. McDowell, M. P. Krebs, and S. Kaushal. 2008. A Combinatorial High-Throughput Screening Method for Small Molecule Pharmacological Chaperones of Misfolded Rhodopsin. Invest Ophthalmol Vis Sci. 49(7)3224-3230. PMID: 18378578

25. Hernández Prada J. A., A. J. Ferreira, M. J. Katovich, V. Shenoy, Y. Qi, R. A. Santos, R. K. Castellano, A. J. Lampkins, V. Gubala, D. A. Ostrov, and M. K. Raizada. 2008. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008 May;51(5):1312-7. PMID: 18391097

26. Magis, A. T., K. M. Bailey, E. V. Kurenova, J. A. Hernández Prada, W. G. Cance, and D. A. Ostrov, 2008. Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group. Acta Crystallogr Sect F Struct Biol Cryst Commun. Jun 1;64(Pt 6):564-6. PMCID: PMC2496861

27. Cannon J. P., R. N. Haire, A. T. Magis, D. D. Eason, K. N. Winfrey, J. A. Hernandez Prada, K. M. Bailey, J. Jakoncic, G. W. Litman and D. A. Ostrov. 2008. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity. 29(2):228-37. PMCID: PMC2603606

28. McDoom I., X. Ma, A. Kirabo, K.Y. Lee, D.A. Ostrov, and P.P. Sayeski. 2008. Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation. Biochemistry. 47(32):8326-34. PMID: 18363744

29. Sayyah J., A. Magis, D.A. Ostrov, R.W. Allan, R.C. Braylan, and P.P. Sayeski. 2008. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther. 7(8):2308-18. PMCID: PMC2479271

30. Golubovskaya V.M., C. Nyberg, M. Zheng, F. Kweh, A. Magis, D. Ostrov, and W.G. Cance. 2008. A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth. J Med. Chem. 51(23):7405-7416. PMCID: PMC2662449

31. Ferreira A.J., V. Shenoy, Y. Yamazato, S. Sriramula, J. Francis, L. Yuan, R.K. Castellano, D.A. Ostrov, S.P. Oh, M.J. Katovich, M.K. Raizada. 2009. Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension. Am J Respir Crit Care Med. Jun 1;179(11):1048-5. PMID: 19246717

32. Holliday L.S., D.A. Ostrov, T.J. Wronski, C. Dolce. 2009. Osteoclast polarization and orthodontic tooth movement. Orthod Craniofac Res. 12(2):105-12. Review. PMID: 19419453

33. Ostrov D.A., A.T. Magis, T.J. Wronski, E.K. Chan, E.J. Toro, R.E. Donatelli, K. Sajek, I.N. Haroun, M.I. Nagib, A. Piedrahita, A. Harris, L.S. Holliday. 2009. Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening. J Med. Chem. 52(16):5144–5151. PMID: 19630402

34. Kurenova E.V., D.L. Hunt, D. He, A.T. Magis, D.A. Ostrov, W.G. Cance. 2009. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem. 52(15):4716-24. PMID: 19610651

35. Hochwald S.N., C. Nyberg, M. Zheng, D. Zheng, C. Wood, N.A. Massoll, A. Magis, D. Ostrov, W.G. Cance, V.M. Golubovskaya. 2009. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 8(15):2435-43. Epub 2009 Aug 1. PMID: 19571674

36. Zheng D., E. Kurenova, D. Ucar, V. Golubovskaya, A. Magis, D. Ostrov, W.G. Cance, S.N. Hochwald. 2009. Targeting of the protein interaction site between FAK and IGF-1R. Biochem Biophys Res Commun. 388(2):301-5. Epub 2009 Aug 5. PMID: 19664602

37. Corsino P., N. Horenstein, D. Ostrov, T. Rowe, M. Law, A. Barrett, G. Aslanidi, W.D. Cress, B. Law. 2009. A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism. J Biol. Chem. 284(43):29945-29955. PMID: 19710018

38. McCormack W., D. Ostrov. 2009. Immunology Team-Based Learning: Receptor Diversity & Antigen Presentation. MedEdPORTAL.

39. Jaiswal A.S., S. Banerjee, H. Panda, C.D. Bulkin, T. Izumi, F.H. Sarkar, D.A. Ostrov, S. Narayan. 2009. A Novel Inhibitor of DNA Polymerase {beta} Enhances the Ability of Temozolomide to Impair the Growth of Colon Cancer Cells. Mol Cancer Res. 7(12):1973-1983. Epub 2009 Dec. 8. PMID: 19996303

40. Cannon J.P., L.J. Dishaw, R.N. Haire, R.T. Litman, D.A. Ostrov, G.W. Litman. 2010. Recognition of additional roles for immunoglobulin domains in immune function. Semin. Immunol. 22(1):17-24. Epub 2009 Dec. 8. PMID: 20004115

41. Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov D.A. 2011. Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):221-3. Epub 2011 Jan 22. PMID: 21301090

42. Jaiswal AS, Banerjee S, Aneja R, Sarkar FH, Ostrov D.A., Narayan S. DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer. PLoS One. 2011 Feb 2;6(2):e16691. PMID: 21311763

43. Xu Z, Vallurupalli A, Fuhrman C, Ostrov D, Morel L. A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells. J Immunol. 2011 Apr 1;186(7):4130-9. Epub 2011 Feb 18. PMID: 21335485

44. Hamazaki T, Leung WY, Cain BD, Ostrov D.A., Thorsness PE, Terada N. Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. PLoS One. 2011 Apr 21;6(4):e19250. PMID: 21532989.

45. Pillai P, Desai S, Patel R, Sajan M, Farese R, Ostrov D, Acevedo-Duncan M. A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. Int J Biochem Cell Biol. 2011 May;43(5):784-94. PMID: 21315177

46. Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov D.A., Johnson JA, Stacpoole PW. Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate. J Clin Pharmacol. 2011 Jun 3. PMID: 21642471

47. Ucar DA, Cox A, He DH, Ostrov D.A., Kurenova E, Hochwald SN. A Noel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma. Anticancer Agents Med Chem. 2011 Jun 27. [Epub ahead of print] PMID: 21707510

48. Ucar DA, Kurenova EV, Garrett TJ, Cance WG, Nyberg CD, Cox AL, Massoll NA, Ostrov D.A., Lawrence NJ, Sebti SM, Hochwald SN. Disruption of the protein interaction between FAK and IGF-R1 inhibits melanoma tumor growth. Carcinogenesis. 2011 Jul 19. [Epub ahead of print] PMID: 21666222

49. Kulemina LV, Ostrov D.A. Prediction of off-target effects on angiotensin-converting enzyme. J Biomol Screen. 2011 Sep;16(8):878-85. Epub 2011 Aug 22.PMID: 21859683 [PubMed – indexed for MEDLINE]

50. Ostrov D.A., Contag CH. Molecular imaging of inflammation and carcinogenesis. Cancer Prev Res (Phila). 2011 Oct;4(10):1523-6. PMID: 21972077 [PubMed – indexed for MEDLINE]

51. Toro EJ, Ostrov D.A., Wronski TJ, Holliday LS. Rational identification of enoxacin as a novel V-ATPase-directed Osteoclast Inhibitor. Curr Protein Pept Sci. 2011 Oct 25. [Epub ahead of print] PMID: 22044158

52. Michels AW, Ostrov D.A., Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. PMID: 22043012 [PubMed – indexed for MEDLINE]

53. Golubovskaya V, Palma NL, Zheng M, Ho B, Magis A, Ostrov D.A., Cance WG. A Small-Molecule Inhibitor, 5′-O-Tritylthymidine, Targets FAK And Mdm-2 Interaction, And Blocks Breast And Colon Tumorigenesis In Vivo. Anticancer Agents Med Chem. 2012 Jan 31. [Epub ahead of print] PMID: 22292771

54. Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov D.A., Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Feb 11;94(1):18-24. [Epub ahead of print] PMID: 22343093

55. Haire RN, Cannon JP, O’Driscoll ML, Ostrov D.A., Mueller MG, Turner PM, Litman RT, Litman GW, Yoder JA. Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family. Genomics. 2012 Feb 21. [Epub ahead of print] PMID: 22386706

56. Demir A, Oguariri RM, Magis A, Ostrov D.A., Imamichi T, Dunn BM.Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells. Antivir Ther. 2012 Mar 20. doi: 10.3851/IMP2090. [Epub ahead of print] PMID: 22436331

57. Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov D.A., Gelman IH, Cance WG. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. Carcinogenesis. 2012 Mar 29. [Epub ahead of print] PMC3334519

58. Toro EJ, Zuo J, Ostrov D.A., Catalfamo D, Bradaschia-Correa V, Arana-Chavez V, Caridad AR, Neubert JK, Wronski TJ, Wallet SM, Holliday LS. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J Biol Chem. 2012 Apr 2. [Epub ahead of print PMCID 3366803.

59. Ostrov D.A., Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64. Epub 2012 May 29. PubMed PMID: 22645359; PubMed Central PMCID: PMC3382472.

60. Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov D.A., Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle. 2012 Sep 1;11(17):3250-9. Epub 2012 Aug 16. PubMed PMCID346652.

61. Arvan P, Pietropaolo M, Ostrov D. A., Rhodes CJ. Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a007658. doi: 10.1101/cshperspect.a007658. PubMed PMCID 3405822.

62. Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov D.A. The structural basis of HLA-associated drug hypersensitivity syndromes. Immunol Rev. 2012 Nov;250(1):158-66. doi: 10.1111/j.1600-065X.2012.01163.x. PubMed PMID: 23046128.

63. Herzog, RW, Ostrov D.A. Immunology. A decorated virus cannot hide. Science. 2012 Nov 9; 338 (6108): 748-9. Doi: 10.1126/science.1230342. PubMed PMID: 23139318.

64. Martino A.T., Basner-Tschakarjan E., Markusic D.M., Finn J.D. Hinderer C., Zhou S., Ostrov D.A., Srivastava A., Ertl H.C., Terhorst C., High K.A., Mingozzi F., Herzog R.W. Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells. Blood. 2013 Mar 21; 121 (12): 2224-33. doi: 10.1182/blood-2012-10-460733. Epub 2013 Jan 16. PubMed PMID: 23325831.

65. Salvador L.A., Taori K., Biggs J.S., Jakoncic J., Ostrov D.A., Paul V.J., Luesch H. Potent elastase inhibitors from cyanobacteria: structural bases and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem. 2013 Fe 14; 56 (3): 1276-90. doi: 10.1021/jm3017305. Epub 2013 Jan 28. PubMed PMID: 23350733.

66. Golubovskaya, V.M., Ho B., Zheng M., Magis A., Ostrov D.A., Morrison C., Cance W.G. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11; 13(1):342. PMC3712010.

67. Leung, W.Y., Hamazaki T., Ostrov D.A., Terada N. Identification of adenine nucleotide translocase 4 inhibitors by molecular docking. J Mol Graph Model. 2013 Sep;45:173-9. Epub 2013 Sep 4. PubMed PMID 24056384.