Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

November 25, 2019

Nature Immunology, Published online: 25 November 2019; doi:10.1038/s41590-019-0539-2Oxidized host-derived phospholipids such as oxPAPC can play important roles in atherosclerosis. Zanoni and...

Specificity meets function

November 19, 2019

Nature Immunology, Published online: 19 November 2019; doi:10.1038/s41590-019-0540-9Specificity and function are the two main aspects that define T cell biology. A new report provides a technology...

cDC2 subsets

November 19, 2019

Nature Immunology, Published online: 19 November 2019; doi:10.1038/s41590-019-0552-5cDC2 subsets

Cytokines in the balance

November 19, 2019

Nature Immunology, Published online: 19 November 2019; doi:10.1038/s41590-019-0557-0Cytokines have context-dependent roles that dictate their normal physiological function; however, dysregulation or...

Flip the coin: IL-7 and IL-7R in health and disease

November 19, 2019

Nature Immunology, Published online: 19 November 2019; doi:10.1038/s41590-019-0479-xThe cytokine IL-7 plays essential roles in lymphocyte development. In their Review, Barata, Durum and Seddon...