Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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CD8 helps TCR catch slippery self pMHC

November 12, 2018

CD8 helps TCR catch slippery self pMHCCD8 helps TCR catch slippery self pMHC, Published online: 12 November 2018; doi:10.1038/s41590-018-0261-5A new model proposes that an applied force allows the...

A TCR mechanotransduction signaling loop induces negative selection in the thymus

November 12, 2018

A TCR mechanotransduction signaling loop induces negative selection in the thymusA TCR mechanotransduction signaling loop induces negative selection in the thymus, Published online: 12 November 2018;...

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4<sup>+</sup>CD8<sup>+</sup> thymocytes

November 12, 2018

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytesTCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of...

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

November 12, 2018

Metabolic reprogramming of natural killer cells in obesity limits antitumor responsesMetabolic reprogramming of natural killer cells in obesity limits antitumor responses, Published online: 12...

TCF-1 takes HEB up a Notch

November 12, 2018

TCF-1 takes HEB up a NotchTCF-1 takes HEB up a Notch, Published online: 12 November 2018; doi:10.1038/s41590-018-0263-3Transcription factors orchestrate stage-specific gene expression during...