Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Denisovan, modern human and mouse <i>TNFAIP3</i> alleles tune A20 phosphorylation and immunity

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0492-0A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human...

Modulation by hypusination

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0508-9Modulation by hypusination

Nuclear viral sensors

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0507-xNuclear viral sensors

Mechanosensing through immunoreceptors

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0491-1Zhu and colleagues discuss the forces that affect the ligand recognition, receptor triggering and signal...

Tolerance factor

September 18, 2019

Nature Immunology, Published online: 18 September 2019; doi:10.1038/s41590-019-0506-yTolerance factor