Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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PD-1<sup>+</sup> T<sub>reg</sub> cells: a foe in cancer immunotherapy?

September 24, 2020

Nature Immunology, Published online: 24 September 2020; doi:10.1038/s41590-020-0801-7The mechanisms that drive responses to PD-1-blocking immunotherapy in some but not all patients have been puzzling....

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

September 23, 2020

Nature Immunology, Published online: 23 September 2020; doi:10.1038/s41590-020-0797-zThe activation of the Notch4–Wnt–GDF15 axis in induced regulatory T (Treg cells) dampens their immunoregulatory...

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

September 21, 2020

Nature Immunology, Published online: 21 September 2020; doi:10.1038/s41590-020-0783-5Phagocytes can acquire lipids and this modulates their function in a variety of disease states, such as...

Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity

September 21, 2020

Nature Immunology, Published online: 21 September 2020; doi:10.1038/s41590-020-00809-wPublisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity

IL-17: good fear no tears

September 21, 2020

Nature Immunology, Published online: 21 September 2020; doi:10.1038/s41590-020-0792-4Cytokines are well-known mediators of the immune response, but, recently, pleiotropic roles in the central nervous...