Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

April 1, 2020

Nature Immunology, Published online: 01 April 2020; doi:10.1038/s41590-020-0670-0Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0633-5Autoreactive T cells are subject to continuous antigenic stimulation yet sustain their autoreactive functionality....

The persistence of stemness

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0644-2Epigenetic modifications are associated with distinct stages of autoreactive CD8+ T cell differentiation. DNA...

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0641-5Therapeutic irradiation can trigger DNA-sensing pathways and trigger antitumor immunity. Fu and colleagues demonstrate...

Sestrins induce natural killer function in senescent-like CD8<sup>+</sup> T cells

March 30, 2020

Nature Immunology, Published online: 30 March 2020; doi:10.1038/s41590-020-0643-3Akbar and colleagues show that sestrins induce the reprogramming of non-proliferative, senescent-like...