Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Drama out of a crisis: the cultural sector responds to healthcare professionals impacted by COVID-19

July 1, 2020

Nature Immunology, Published online: 01 July 2020; doi:10.1038/s41590-020-0734-1Support for healthcare workers impacted by COVID-19 comes from the performing arts.

The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development

June 29, 2020

Nature Immunology, Published online: 29 June 2020; doi:10.1038/s41590-020-0713-6Generation of memory B cells is crucial for protective immunity to infectious agents. Cyster and colleagues show that...

Plague as a cause for familial Mediterranean fever

June 29, 2020

Nature Immunology, Published online: 29 June 2020; doi:10.1038/s41590-020-0724-3Evolutionary genetic and experimental analyses suggest that mutations causing familial Mediterranean fever have been...

Ancient familial Mediterranean fever mutations in human pyrin and resistance to <i>Yersinia pestis</i>

June 29, 2020

Nature Immunology, Published online: 29 June 2020; doi:10.1038/s41590-020-0705-6Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin...

Chd4 choreographs self-antigen expression for central immune tolerance

June 29, 2020

Nature Immunology, Published online: 29 June 2020; doi:10.1038/s41590-020-0717-2Takayanagi and colleagues show that the chromatin remodeler Chd4 works with both Fezf2 and Aire to promote promiscuous...