Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Ion Gresser 1928–2019

June 10, 2019

Nature Immunology, Published online: 10 June 2019; doi:10.1038/s41590-019-0428-8Ion Gresser 1928–2019

IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?

June 10, 2019

Nature Immunology, Published online: 10 June 2019; doi:10.1038/s41590-019-0424-zThe cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals...

The deubiquitinase Otub1 controls the activation of CD8<sup>+</sup> T cells and NK cells by regulating IL-15-mediated priming

June 10, 2019

Nature Immunology, Published online: 10 June 2019; doi:10.1038/s41590-019-0405-2IL-15 has important functions in the activation and homeostasis of cytotoxic T lymphocytes (CTLs) and NK cells. Sun and...

Author Correction: Activated β-catenin in Foxp3<sup>+</sup> regulatory T cells links inflammatory environments to autoimmunity

June 7, 2019

Nature Immunology, Published online: 07 June 2019; doi:10.1038/s41590-019-0438-6Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

June 3, 2019

Nature Immunology, Published online: 03 June 2019; doi:10.1038/s41590-019-0400-7Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules....