Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Deconvoluting global cytokine signaling networks in natural killer cells

April 15, 2021

Nature Immunology, Published online: 15 April 2021; doi:10.1038/s41590-021-00909-1Sun and colleagues provide a new resource, multi-omics analysis of NK cell Jak–STAT signaling in response to the...

Microglia use TAM receptors to detect and engulf amyloid β plaques

April 15, 2021

Nature Immunology, Published online: 15 April 2021; doi:10.1038/s41590-021-00913-5How microglia sense amyloid plaques in Alzheimer’s disease has remained mysterious. Lemke and colleagues report that...

NK cell memory: discovery of a mystery

April 15, 2021

Nature Immunology, Published online: 15 April 2021; doi:10.1038/s41590-021-00890-9Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in...

TAM-ping down amyloid in Alzheimer’s disease

April 15, 2021

Nature Immunology, Published online: 15 April 2021; doi:10.1038/s41590-021-00918-0The TAM receptor kinases Axl and Mer are critical for microglial recognition and clearance of accumulating amyloid in...

COVID-19 research and science in the service of public health: the example of Greece

April 13, 2021

Nature Immunology, Published online: 13 April 2021; doi:10.1038/s41590-021-00919-zThe COVID-19 response in Greece has been swift and flexible, adapting to the evolving pandemic and creating unique...