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Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Receptor for new PAMPs

September 18, 2014

Continued mission of ThPOK

September 18, 2014

ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the...

Emerging functions of the unfolded protein response in immunity

September 18, 2014

The ER stress response is a well-characterized process aimed at restoring ER function. Lambrecht et al. explore how ER stress can also intersect with the innate and adaptive immune response at...

Neutrophils worm their way into macrophage long-term memory

September 18, 2014

Neutrophil function is perhaps best studied in bacterial infection, during which they are directly involved in pathogen killing. After helminth invasion, however, neutrophils acquire an alternative...

Restricting plasma cells

September 18, 2014