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Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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CCR7 polysialylation

January 19, 2016

Central tolerance: what you see is what you don't get!

January 19, 2016

Thymic selection shapes the repertoire of potentially autoreactive thymocytes that are allowed to mature. The expression pattern of self antigen seen by thymocytes determines the number and functional...

Decoding the immune response to successful influenza vaccination

January 19, 2016

Systems immunology identifies molecular and cellular signatures associated with adverse clinical events and antibody response to a vaccine against H1N1 influenza virus.

Multilayered ancestry of arterial macrophages

January 19, 2016

Arteries are colonized by macrophages of multiple origins, derived prenatally from the yolk sac and during an early postnatal wave from the bone marrow. During sepsis, blood monocyte-derived...