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Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Development of innate lymphoid cells

June 21, 2016

Innate lymphoid cells (ILCs) arise from distinct hematopoietic progenitors. Zook & Kee discuss the transcriptional programs that direct the development of natural killer cells and various ILC...

A versatile cell population

June 21, 2016

Innate lymphoid cells serve multiple roles in maintaining tissue homeostasis and responding to tissue insults and can contribute to chronic inflammatory diseases.

Family ties among CNS macrophages

June 21, 2016

Perivascular and subdural meningeal macrophages at the interface between the central nervous system and the periphery are self-renewing and arise from early embryonic precursors. Macrophages residing...

Bach2 is required for B cell and T cell memory differentiation

June 21, 2016

B cell and T cell memory differentiation requires the transcription factor Bach2, which inhibits the effector-cell fate by limiting antigen-receptor-stimulation-induced gene expression and restricting...