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Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Metastasis factor

September 18, 2015

Subversion of anticancer immunosurveillance by radiotherapy

September 18, 2015

Paradoxically, radiotherapy can reinforce immunosuppressive pathways that undermine anticancer immunosurveillance and treatment efficacy. Irradiation induces Langerhans cells to migrate from the skin...

Autophagy and autophagy-related proteins in the immune system

September 18, 2015

Autophagy is an essential intracellular degradation process. Yoshimori and colleagues review the broad role of autophagy in immunological function.

To κ+ B or not to κ+ B

September 18, 2015

Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized...