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Recent data suggest alternative mechanisms that promote HLA-associated drug syndromes.

Abacavir binds within the antigen-binding cleft of human leukocyte antigen (HLA)-B*57:01. Read more about it here.

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Molecular Mountaineers

UF drug development researchers are forging new trails to cancer treatments. Read about it here.

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Drug Discovery

We use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined […]

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Nature ImmunologySubscribe to this RSS Feed

cASCading specks

July 21, 2014

Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC; this perpetuates the innate immune...

Peroxisomal MAVS activates IRF1-mediated IFN-λ production

July 21, 2014

Infection with an RNA virus induces the interferons IFN-β and IFN-λ via the adaptor MAVS located in mitochondria, while peroxisomal MAVS selectively activates an IFN-λ response.

Writing well: lowering the barriers to success

July 21, 2014

It is not enough to be a good scientist. One needs to be a good communicator. When publications are clear and a pleasure to read, they will advance both the field and the authors' reputation.